Tilidine ratiopharm plus 200 mg/16 mg prolonged Active ingredients: tilidine hemihydrate and naloxone hydrochloride dihydrate
first What is tilidine ratiopharm plus 200 mg/16 mg and what is it used? Tilidin mg-ratiopharm plus 200 mg/16 a combination of a potent pain reliever from the group of opioids and opioid antagonists.
tilidine ratiopharm plus 200 mg/16 mg is used to - treat severe and very severe pain.
second You take mg before taking tilidine ratiopharm plus 200 mg/16? tilidine ratiopharm plus 200 mg/16 mg Do not take - If you are hypersensitive (allergic) mg compared tilidine-Hemidrat, naloxone hydrochloride dihydrate or any of the other ingredients of tilidine ratiopharm plus 200 mg/16
- are for drug addiction of opiates (heroin, morphine) or opioids because of the danger immediately occurring withdrawal symptoms
- of children and adolescents under 18 years
With other addictions (eg drug or alcohol addiction), you should not take tilidine ratiopharm plus 200 mg/16 mg. Consult your doctor for this. This also applies if you suffer once in a dependence disorder.
In severe liver dysfunction (Eg severe liver cirrhosis) should be Tilidin-ratiopharm plus 200 mg/16 mg taken not, as it can get mg loss of effect of tilidine ratiopharm plus 200 mg/16. Talk to your doctor in this case.
special care when taking tilidine ratiopharm plus 200 mg/16 mg is required mg before any abuse of tilidine ratiopharm plus 200 mg/16 by drug addicts is urgently warned!
For opiate addicts, who take as a substitute for opiates such as morphine or heroin, the drug abuse in high income levels, triggers tilidine ratiopharm plus 200 mg/16 mg of acute withdrawal symptoms or strengthen existing Withdrawal symptoms.
tilidine ratiopharm plus 200 mg/16 mg is not suitable for detoxification treatment!
children tilidine ratiopharm plus 200 mg/16 mg should not be used in children and adolescents under 18 years, since there is no experience.
Taking tilidine ratiopharm plus 200 mg/16 mg with other drugs Please tell your doctor or pharmacist if you are taking other medicines or have recently taken any medicines, even if it is without a prescription. mg
Concomitant administration of tilidine ratiopharm plus 200 mg/16 and alcohol or Depressants, there is a mutual reinforcement and extension of the effects on the central nervous system.
For further application on the central nervous system damping acting drugs in individual cases, inhibition of respiration may occur.
tilidine ratiopharm plus 200 mg/16 mg should not be taken with other pain relievers that act in the same manner as Tilidine (opioids), because the interaction through mutual influence can be estimated.
In some cases, patients who received tilidine ratiopharm plus 200 mg/16 mg and duration of treatment with warfarin (blood clotting drugs) were a Quick drop in the value observed. Therefore, the control of the prothrombin time in the beginning and the end of treatment with tilidine be ratiopharm plus 200 mg/16 mg closely in order to adjust the dose of warfarin accordingly.
Please note that this information might also apply to recently of a drug.
Taking tilidine ratiopharm plus 200 mg/16 mg with food and drinks Concomitant use with alcohol should not take place.
pregnancy and lactation Ask around before taking any medicine your doctor or pharmacist Council
tilidine ratiopharm plus 200 mg/16 mg during pregnancy should be given only after strict risk-benefit assessment, as no experience in humans.
tilidine ratiopharm plus 200 mg/16 mg during lactation should be given only after strict risk-benefit assessment, as no experience in humans.
Is breast-feeding, treatment absolutely necessary, should not be stopped.
drive and use machines tilidine ratiopharm plus 200 mg/16 mg may affect the attention and responsiveness. You can then in an unexpected and sudden Events quickly enough, and not specifically to respond. Do not drive car or other vehicles! Do not work without a secure grip! A stronger effect is likely to occur in the beginning of treatment, dose increase, change, and preparations in combination with alcohol or taking sedatives. They may not engage in such activities only if it allows you to express your physician. Discuss with your doctor whether and under what conditions you can drive, for example, car.
third What is tilidine ratiopharm plus 200 mg/16 mg to take? Take tilidine ratiopharm plus 200 mg/16 mg exactly as directed of a physician. Please check with your doctor or pharmacist if you are not sure.
If your doctor prescribes otherwise, the usual dose is Tilidin-ratiopharm plus 200 mg/16 mg, particularly for the treatment of chronic pain. The dose is determined by the physician for each patient individually.
The daily dose, depending on pain severity and individual response to treatment, between 100 mg and a maximum of 600 mg (based on tilidine) lie.
The usual starting dose is 100 mg 2 times daily tilidine. It should be a time lag of 12 hours maintained between the revenue be.
If you have not taken any opioid, will decrease your doctor if the initial dose to 2 times daily 50 mg tilidine.
Is the pain treatment with 2-times daily 100 mg tilidine not enough, your doctor will gradually increase the dosage up to a dose that achieves adequate pain control with tolerable side effects.
tilidine ratiopharm plus 200 mg/16 mg is suitable for a daily dose of 400 mg (based on tilidine).
adults take 2 times a day 1 release tablet tilidine ratiopharm plus 200 mg/16 mg (equivalent to 400 mg per day tilidine) a.
other dosages are required to stand for tilidine ratiopharm plus 50 mg / 4 mg, tilidine ratiopharm plus 100 mg / 8 mg and tilidine ratiopharm plus 150 mg/12 mg as other thicknesses. All tablet strengths may be combined if necessary.
Note: These recommended dosages are
guidelines. In individual cases, to treat very severe pain to exceed the maximum dose and shortening the interval of income are necessary.
dose in renal impairment Renal impairment does not require dose modification.
dosage in elderly patients dosage adjustment in elderly patients is not necessary.
type of application The release tablets are without food swallowed whole with liquid.
The release tablets should not be divided, since this reduces the delayed release of the active ingredients is no longer guaranteed.
Take tilidine ratiopharm plus 200 mg/16 mg determined by your doctor after the fixed time schedule (eg morning at 8:00 in the evening at 20.00 clock and clock).
duration of application The duration of use is determined by your doctor.
principle If the small amount of analgesic administration can be selected.
experience in long-term therapy are documented in some cases, for a period of more than 2 years.
to MG after protracted administration of tilidine ratiopharm plus 200 mg/16 the drug should not be discontinued abruptly. The dose reduction should be gradual as directed by your doctor.
Please talk to your doctor or pharmacist if you have the impression that the effect of tilidine ratiopharm plus 200 mg/16 mg is too strong or too weak. should
If you take more of tilidine ratiopharm plus 200 mg/16 mg than you If you make an Single dose of tilidine take ratiopharm plus 200 mg/16 mg twice, this can lead to increased side effects described in the phenomena.
comes after taking it much too high drug amounts to dizziness, drowsiness, nausea, vomiting, ataxia (failure in the ordered sequence of movements), restlessness and increased reflexes. For very large overdose can cause a reduction of breathing occur.
you call if they experience these symptoms the next available physician to help!
possible treatment measures are the primary removal of the drug by gastric lavage, administration Resorptionsverminderung by coal, Circuit stabilization by electrolyte infusions and improvement of respiratory function by oxygen inhalations and controlled ventilation. At excitatory symptoms diazepam intravenously in the usual dosage. As an antidote, naloxone, intravenous (eg 0.4 mg) were administered.
If you forget to take tilidine ratiopharm plus 200 mg/16 mg Do not take a double dose to make up for a forgotten dose.
If you miss a dose, this leads to inadequate or lack of pain relief. You can make up the tablets, when the next regular income provided in more than 8 hours was. Then you can keep the original revenue plan.
If the period until the next dose less than 8 hours, remove the release tablet too, but shifts the revenue plan now. Please talk about the next steps with your doctor. Basically, you should tilidine ratiopharm plus 200 mg/16 mg to take no more frequently than every 8 hours.
If you stop taking tilidine ratiopharm plus 200 mg/16 mg cancel
interrupt treatment without first consulting your doctor.
If you have further questions on the use of this medicine, ask your doctor or pharmacist.
4th What Possible side effects? Like all medicines, have tilidine ratiopharm plus 200 mg/16 mg side effects, although not everybody gets them.
The assessment of adverse events following frequencies are used:
very common: often more than 1 in 10
: sometimes less than 1 to 10, but more than 1 in 100
: less seldom as 1 to 100, but more than 1 in 1000
: less than 1 to 1000, but more than 1 in 10,000
very rare less than 1 in 10,000, or unknown
able to start treatment very often experience nausea and vomiting that occur with further treatment, only occasionally to frequently.
occasionally connect to, dizziness, fatigue and dizziness. About diarrhea, nonspecific abdominal pain, increased sweating and headache were reported.
To counteract effects of this kind is recommended that the patient - as is common in severe pain - no physical strain and undergoes lie down if they experience dizziness.
impairment of the hematopoietic system, kidney or liver functions tilidine ratiopharm plus 200 mg/16 mg have not been observed.
countermeasures If unpleasant side effects, your doctor will discuss with you which countermeasures exist for this and whether other drugs get the treatment in question.
please inform your doctor or pharmacist if any of the side effects gets serious, or if you notice any side effects not listed in this leaflet. 5th What is tilidine ratiopharm plus 200 mg/16 mg to store? medicines away from children.
the medicine after the on given the carton and the blister packs expiration date no longer use. The expiry date refers to the last day of the month.
not store above 30 ° C.
6th For more information What tilidine ratiopharm plus 200 mg/16 mg contains The active ingredients are tilidine hemihydrate and naloxone hydrochloride dihydrate.
Each sustained release tablet contains 205.82 mg tilidine hemihydrate equivalent to 200 mg and 17.6 mg tilidine naloxone hydrochloride dihydrate equivalent to 16 mg naloxone hydrochloride.
The other ingredients are:
hypromellose, microcrystalline cellulose, colloidal silicon dioxide, Magnesium stearate (Ph.Eur.), Titanium dioxide (E171), macrogol 400th
How tilidine ratiopharm plus 200 mg/16 mg looks like and contents of the pack oblong, biconvex, white tablets.
Tilidin mg-ratiopharm plus 200 mg/16 available in packs of 20, 50 and 100 tablets.
Pharmaceutical company ratiopharm GmbH Graf-Arco-Str. 3
89079 Ulm
www.ratiopharm.de
manufacturer Merckle GmbH Ludwig-Merckle-Str
. 3
89143 Blaubeuren
This leaflet was last revised in May 2007
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